近日，在舉辦的2017年美國(guó)腎臟病學(xué)會(huì)腎臟周上，來(lái)自葡萄牙的研究人員表示，咖啡因的攝入或會(huì)延長(zhǎng)慢性腎臟疾?。–KD）患者的壽命。在一般人群中咖啡因的攝入與機(jī)體長(zhǎng)壽直接相關(guān)，為了觀察是否這種效應(yīng)也存在于腎臟疾病患者中，研究人員通過(guò)對(duì)2328名CKD患者進(jìn)行了一項(xiàng)隊(duì)列前瞻性研究來(lái)觀察攝入咖啡因和參與者死亡率的關(guān)系，這些參與者在1999年至2010年間參與了國(guó)家的連續(xù)健康與營(yíng)養(yǎng)狀況調(diào)查。

研究者發(fā)現(xiàn)，咖啡因和全因死亡率之間或許存在一種劑量依賴的負(fù)相關(guān)關(guān)系，相比最低四分位數(shù)咖啡因攝入水平的人群而言，第二、第三和最高四分位數(shù)咖啡因攝入水平的個(gè)體的死亡風(fēng)險(xiǎn)分別會(huì)降低12%、22%和24%。

研究者Bigotte Vieira博士表示，我們的研究闡明了慢性腎臟疾病患者中咖啡因攝入和死亡率之間的一種劑量依賴性的保護(hù)效應(yīng)，這種關(guān)系并不依賴于潛在的多種因素，包括年齡、性別、種族、每年的家庭收入、教育水平、大概的腎小球?yàn)V過(guò)率（GFR）、肌酐比值、高血壓、吸煙狀況、血脂異常、體重指數(shù)、此前的心血管事件和飲食（酒精攝入、碳水化合物、多不飽和脂肪酸和纖維）。

最后研究者說(shuō)道，本文研究結(jié)果表明，建議慢性腎臟疾病患者多攝入咖啡因或能有效降低其死亡率，這或許闡明了一種簡(jiǎn)單、臨床有益的選擇方式，盡管研究人員認(rèn)為這種結(jié)果最好是在隨機(jī)臨床試驗(yàn)中進(jìn)行證實(shí)，他們認(rèn)為，觀察性的研究并不能說(shuō)明，咖啡因能夠降低慢性腎臟疾病患者的死亡風(fēng)險(xiǎn)，但這只是暗示了諸如這種保護(hù)效應(yīng)的可能性。（生物谷Bioon.com）

原始出處：

Caffeine consumption may help kidney disease patients live longer

Caffeine consumption may prolong the lives in patients with chronic kidney disease (CKD), according to a study that will be presented at ASN Kidney Week 2017 October 31-November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.

Coffee consumption has been linked to a longer life in the general population. To see if this holds true for individuals with CKD, Miguel Bigotte Vieira, MD (Centro Hospitalar Lisboa Norte, in Portugal), and his colleagues examined the association of caffeine consumption with mortality among 2328 patients with CKD in a prospective US cohort, using the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2010.

The team found a dose-dependent inverse association between caffeine and all-cause mortality. Compared with those in the lowest quartile of caffeine consumption, those in the second, third, and highest quartiles had 12%, 22%, and 24% lower risks of dying.

"Our study showed a dose-dependent protective effect of caffeine consumption on mortality among patients with CKD. This association was independent of potential confounders including age, gender, race, annual family income, education level, estimated GFR, albumin/creatinine ratio, hypertension, smoking status, dyslipidemia, body mass index, previous cardiovascular events and diet: consumption of alcohol, carbohydrates, polyunsaturated fatty acids, and fibers," said Dr. Bigotte Vieira......